University of California, Riverside

School of Medicine



Faculty Biographies


Devin Binder

Associate Professor in Residence

 Devin Binder

University of California, Riverside
Riverside, CA 92521

Tel: (951) 827-2224
E-mail: devin.binder@ucr.edu
Office: 1247 Webber Hall

Education and Training

  • M.D./Ph.D. Duke University
  • Internship & Residency, UC San Francisco
  • Fellowship, University of Bonn

Previous Institution

  • UC Irvine School of Medicine

Biography

Dr. Devin K. Binder, M.D., Ph.D. is an associate professor in residence in the Department of Biomedical Sciences at the University of California, Riverside.

Binder received his M.D. and Ph.D. degrees from Duke University and then undertook an internship in general surgery and a residency in neurological surgery at the University of California, San Francisco. He completed a neurosurgical and neuroscience fellowship at the University of Bonn, as a William P. Van Wagenen Fellow in Germany.

Binder is affiliated with the Society for Neuroscience, the American Society for Neurochemistry, the American Association for the Advancement of Science, the AMA, the American Epilepsy Society, the American Association of Neurological Surgeons, the American Society of Stereotactic and Functional Neurosurgery and the Congress of Neurological Surgeons. 

Research Summary

Our laboratory mission is to apply new discoveries from the basic sciences of glial-neuronal interactions and neurophotonics to create new ways to diagnose and treat neurological diseases. In the collaborative environment of UCR, we are pursuing multiple basic and applied science projects to this end.

Research topics include:

  • Molecular changes in astrocytes after seizures, traumatic brain injury and spinal cord injury.
  • Role of astrocyte swelling in excitability and seizure initiation.
  • Seizure susceptibility in models of brain inflammation, infection, and demyelination.
  • Physiological biomarkers and novel drug targets in mouse models of Fragile X syndrome.
  • Development of optical methods for detection of seizures and brain edema.
  • Development of novel bioengineering methods to directly treat cerebral and spinal edema.
  • Development of optical methods for detection of normal (functional) brain activity.
  • Development of a "window to the brain."

More information can be found at our website.

Awards

  • Physician of Excellence Award, Orange County Medical Association, 2014.
  • Outstanding Achievement in Physician-Patient Communication Award, Department of Surgery, Orange Coast Memorial Medical Center, June 2011.
  • Highly Commended award, Basic and Clinical Sciences category of the 2011 British Medical Association Medical Book Awards for Cranial Nerves: Anatomy, Pathology, Imaging.
  • Excellence in Teaching Award, UCI School of Medicine, 2009.
  • Gold Star Award, Gold Humanism Honor Society, 2009.
  • Vesalius Award, American Association of Neurological Surgeons, 2007.
  • American Epilepsy Society, Milken Family Foundation Early Career Physician Scientist Award, 2006.
  • Van Wagenen Fellowship from the American Association of Neurological Surgeons, 2005.
  • Hoopes Prize, Harvard University.

Selected Publications

  • D.W. McBride, V. Donovan, M.S. Hsu, A. Obenaus, V.G. Rodgers and D.K. Binder. 2016. Reduction of cerebral edema via an osmotic transport device improves functional outcome after traumatic brain injury in mice. Acta Neurochir. Suppl. 121:285-289.
  • J.A. Hubbard, M.S.Hsu, M.M.Seldin and D.K. Binder. 2015. Expression of the astrocyte water channel aquaporin-4 in the mouse brain. ASN Neuro Oct. 21;7(5), pii: 1759091415605486.
  • K. Lauderdale, T. Murphy, T. Tung, D. Davila, D.K. Binder and T.A. Fiacco. 2015. Osmotic edema rapidly increases neuronal excitability through activation of NMDA receptor-dependent slow inward currents in juvenile and adult hippocampus. ASN Neuro Oct. 21;7(5), pii: 759091415605115.
  • M.M. Eberle, M.S. Hsu, C.L. Rodriguez, J.I. Szu, M.C. Oliveira, D.K. Binder and B.H. Park. 2015. Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography. Biomed. Opt. Express 6(5):1812-1827.
  • C.L.R. Rodriguez, J.I. Szu, M.M. Eberle, Y. Wang, M.S. Hsu, D.K. Binder and B.H. Park. 2014. Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography. Neurophotonics 1(2), 025004 (Oct–Dec 2014).
  • D.W. McBride, J.I. Szu, C. Hale, M.S. Hsu, V.G.J. Rodgers and D.K. Binder. 2014. Reduction of cerebral edema following TBI using an osmotic transport device. J. Neurotrauma 31:1948-1954.
  • H.E. Scharfman and D.K. Binder. 2013. Aquaporin-4 water channels and synaptic plasticity in the hippocampus. Neurochem. Int. 63:702-711.
  • J. Hubbard, M.S. Hsu, T.A. Fiacco and D.K. Binder.  2013.  Glial cell changes in epilepsy: overview of the clinical problem and therapeutic opportunities.  Neurochem. Int. (in press).
  • D.K. Binder and S. Haut.  2013.  Toward new paradigms of seizure detection.  Epilepsy & Behavior 26:247-252.
  • J.I. Szu, M.M. Eberle, C.L. Reynolds, M.S. Hsu, Y. Wang, C.M. Oh, M.S. Islam, B.H. Park and D.K. Binder.  2012.  Thinned-skull cortical window technique for in vivo optical coherence tomography imaging.  J. Vis. Exp. Nov 19;(69). doi:pii: 50053. 10.3791/50053.
  • M.M. Eberle, C.L. Reynolds, J.I. Szu, Y. Wang, A.M. Hansen, M.S. Hsu, M.S. Islam, D.K. Binder and B.H. Park.  2012.  In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography.  Biomedical Optics Express 3:2700-2706.
  • D.W. McBride, M.S. Hsu, V.G.J. Rodgers and D.K. Binder.  2012.  Improved survival following cerebral edema using a novel hollow fiber-hydrogel device.   J. Neurosurg. 116:1389-94.
  • D.K. Binder, E.A. Nagelhus and O.P. Ottersen.  2012.  Aquaporin-4 and epilepsy.  Glia 60:1203-1214.
  • D.J. Lee, M.S. Hsu, M.M. Seldin, J.L. Arellano and D.K. Binder.  2012.  Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis.  Exp. Neurol. 235:246-255.
  • D.J. Lee, M. Amini, M.J. Hamamura, M.S. Hsu, M.M. Seldin, O. Nalcioglu and D.K. Binder.  2012.  Aquaporin-4-dependent edema clearance following status epilepticus.  Epilepsy Research 98:264-268.
  • V.A. Skucas, I.B. Mathews, J. Yang, Q. Cheng, A. Treister, A.S. Verkman, B.L. Hempstead, M.A. Wood, D.K. Binder and H.E. Scharfman.  2011.  Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4.  J. Neurosci. 31:6392-6397.
  • S. Strohschein, K. Hüttmann, S. Gabriel, D.K. Binder, U. Heinemann and C. Steinhäuser.  2011.  Impact of aquaporin-4 on K+ buffering and gap junction coupling in the hippocampus.  Glia 59:973-980.
  • M.S. Hsu, M. Seldin, D. Lee, G. Seifert, C. Steinhäuser and D.K. Binder.  2011.  Laminar-specific and developmental expression of aquaporin-4 in the mouse hippocampus.  Neuroscience 178:21-32.
  • A.S. Gill, K.F. Rajneesh, C.M. Owen, J. Yeh, M. Hsu and D.K. Binder.  2011.  Early optical detection of cerebral edema in vivo.  J. Neurosurg. 114:470-477.
  • A. Kimura, M. Hsu, M. Seldin, A.S. Verkman, H.E. Scharfman and D.K. Binder.  2010.  Protective role of aquaporin-4 water channels after contusion spinal cord injury.  Ann. Neurol. 67:794-801.

More Information 

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