University of California, Riverside

School of Medicine

Faculty Biographies

Christian Lytle

Associate Dean, Pre-Clerkship Curriculum
Associate Professor of Biomedical Sciences

Christian Y. Lytle

University of California, Riverside
Riverside, CA 92521

Tel: (951) 827-2592
Fax: (951) 827-5504
Office: 2226 Webber Hall

Education and Training

  • B.A., University of California, Santa Barbara, 1981
  • M.A., University of California, Santa Barbara, 1983
  • Ph.D., Duke University, 1988
  • Postdoctoral Fellow, Yale University, 1989-1993

Research Summary

Our research program is directed at understanding epithelial cell ion transport processes along the intestine. We are especially interested in how these transport processes:

  1. Support stratified communities of beneficial bacteria living within the gut;
  2. Create distinct microenvironments within the mucus coating of the colon;
  3. Give rise to diarrhea in defense against pathogenic intruders;
  4. Become impaired in and contribute to inflammatory bowel disease.

Selected Publications

  • Bahmani, B., C. Lytle, A.M. Walker, V. Vullev, B. Anvari (2013) Effects of Nano-encapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs. International J. Nanomedicine, In press.
  • Subramanian, V.S., A. Ghosal, S. Subramanya, C. Lytle, H.M. Said (2013) Differentiation-dependent regulation of intestinal vitamin B2 uptake: Studies utilizing human-derived intestinal epithelial Caco2 cells and native rat intestine. Am. J. Physiol. Gastro & Liver. Feb 2013. 
  • Antrobus, S., C. Lytle, J.A. Payne (2012) K+-Cl- cotransporter-2 (KCC2) in chicken cardiomyocytes. Am. J. Physiol. (Cell Physiol.); 303:C1180-C1191. 
  • Lau, C., C. Lytle, D.S. Straus, and K.A. DeFea (2011) Apical and basolateral pools of proteinase-activated receptor-2 direct distinct signaling events in the intestinal epithelium. Am. J. Physiol. (Cell Physiol) 300:C113-C123. 
  • Talbot, C., and C. Lytle (2010) Segregation of Na/H exchanger-3 and Cl/HCO3 exchanger SLC26A3 (DRA) in rodent cecum and colon. Am. J. Physiol. (GI & Liver) 299:G358-G367. 
  • Bajwa, P.J., J.W. Lee, D.S. Straus, and C. Lytle (2009) Activation of PPARg by rosiglitazone attenuates intestinal Cl- secretion. Am. J. Physiol. 297:G82-G89. 
  • Bajwa, P.J., A. Alioua, J.W. Lee, D.S. Straus, L. Toro, and C. Lytle. (2007) Fenofibrate inhibits intestinal Cl secretion by blocking basolateral KCNQ1 K+ channels. Am J Physiol. 293:G1288-G1299

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